The hex grids shown in the Guide's maps are sized to common Dungeons & Dragons standards:
Continent maps
Large hexes are 60 miles from side to side.
Small hexes are six miles from side to side. It typically takes one day to explore a six-mile hex at a normal pace.
Kingdom maps
Large hexes are six miles.
Small hexes are half a mile, meaning it takes twelve small hexes to span one large one.
Local maps
Large hexes are half a mile.
Small hexes are 1/24th of a mile, or 220 feet.